Article
Opposing effects of histone H2A.Z on memory, transcription and pathology in male and female Alzheimer’s disease mice and patients
2025-06-01
Abstract excerpt
Alzheimer’s disease (AD) is a devastating neurodegenerative disease that disproportionately impacts women, but underlying mechanisms for sex-divergent outcomes are unknown. Here, we show that the histone variant H2A.Z is a novel sex-specific regulator of AD in human patients and AD model mice. Specifically, H2A.Z binding in chromatin declines in female and increases in male AD patients, indicating opposite pattern...
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Identifiers and source
- Literature Corpus work
- 06b41402-eef2-51c8-93ef-2508a569ad56
- DOI
- 10.1101/2025.05.28.656659