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Microglial response to amyloid-β pathology is modulated by X chromosome dosage

2025-06-04

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) exhibits sex-specific prevalence rates, yet the biological basis of this disparity remains unclear. Microglia, the brain’s resident macrophages, play a central role in neuroinflammation and AD pathogenesis, displaying sex-dependent functional differences. However, whether sex chromosome complement directly affects their immune response is unknown. Here we use is...

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Literature Corpus work
702577e8-600e-5687-9797-54d942b91233
DOI
10.21203/rs.3.rs-6558560/v1
Open publication

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Microglial response to amyloid-β pathology is modulated by X chromosome dosageDOI 10.21203/rs.3.rs-6558560/v1
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