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Article

Sex-specific differences in DNA methylation defining prognostically relevant subgroups in glioblastoma

14 Feb 2025

Abstract excerpt

OBJECTIVE: Glioblastoma is an aggressive brain tumor that is more common and has a worse outcome in males. Recently, the observed sex differences have been linked to tumor biology, prominently highlighting fundamental differences in gene expression programs. Here, the authors advance this concept to epigenome-based DNA methylation patterns across primary and recurring glioblastoma. METHODS: The authors leveraged...

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PMID: 39951709
DOI: 10.3171/2024.9.jns24665

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