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Article

Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma

28 Jun 2023

Abstract excerpt

Sex differences in glioblastoma (GBM) incidence and outcome are well recognized, and emerging evidence suggests that these extend to genetic/epigenetic and cellular differences, including immune responses. However, the mechanisms driving immunologic sex differences are not fully understood. Here, we demonstrate that T cells play a critical role in driving GBM sex differences. Male mice exhibited accelerated tumor...

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PMID: 37378557
DOI: 10.1158/2159-8290.cd-22-0869

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