Article

Single-cell characterization of human GBM reveals regional differences in tumor-infiltrating leukocyte activation

2022-06-19

Abstract excerpt

Glioblastoma (GBM) harbors a highly immunosuppressive tumor microenvironment (TME) which influences glioma growth. Major efforts have been undertaken to describe the TME on a single-cell level. However, human data on regional differences within the TME remain scarce. Here, we performed high-depth single-cell RNA sequencing (scRNAseq) on paired biopsies from the tumor center, peripheral infiltration zone and blood...

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Literature Corpus work: 0b66f7da-785c-5e08-bee7-3fe93f351934
DOI: 10.1101/2022.06.17.496574

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