Article

Inulin and Galacto-oligosaccharides Increase the Genotoxic Effect of Colibactin Produced by pks+ Escherichia Coli Strains

2020-12-07

Abstract excerpt

<title>Abstract</title> <bold>Background: </bold>Colibactin is a genotoxin that induces double-strand DNA breaks and is produced by <italic>Escherichia coli</italic> strains harboring the <italic>pks</italic> island. Human and animal studies have shown that colibactin-producing gut bacteria promote carcinogenesis and enhance the progression of colorectal cancer through cellular senescence and chromosomal abnor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f3813790-f5d1-50d7-a146-641c783a09f5
DOI: 10.21203/rs.3.rs-121125/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inulin and Galacto-oligosaccharides Increase the Genotoxic Effect of Colibactin Produced by pks+ Escherichia Coli StrainsDOI 10.21203/rs.3.rs-121125/v1Read

A toxic friend: Genotoxic and mutagenic activity of the probiotic strain Escherichia coli Nissle 1917Semantic proximity Read

Assessment of Genotoxic Escherichia coli and Helicobacter pylori Pathogenicity in the Context of Gastrointestinal Carcinogenesis in a Turkish CohortSemantic proximity Read

Pks+ Escherichia Coli More Prevalent in Benign than Malignant Colorectal TumorsSemantic proximity Read

A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917.Semantic proximity Read

Contribution of pks+ Escherichia coli (E. coli) to Colon CarcinogenesisSemantic proximity Read

A Mechanistic Model for Colibactin-Induced Genotoxicity.Semantic proximity Read

Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer.Semantic proximity Read

Targeted depletion of pks+ bacteria from a fecal microbiota using specific antibodies.Semantic proximity Read

The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors.Semantic proximity Read

Diversity and prevalence of colibactin- and yersiniabactin encoding mobile genetic elements in enterobacterial populations: insights into evolution and co-existence of two bacterial secondary metabolite determinantsSemantic proximity Read

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.Semantic proximity Read

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavageSemantic proximity Read