Article

Silencing of E-cadherin in induced human pluripotent stem cells promotes extraembryonic fates accompanying multilineage differentiation

2020-11-03

Abstract excerpt

<h4>Summary/Abstract</h4> In embryonic development, symmetry breaking events and the mechanical milieus in which they occur coordinate the specification of separate cell lineages. Here, we use 3D aggregates of human pluripotent stem cells (hPSCs) encapsulated in alginate microbeads to model the early blastocyst prior to zona pellucida hatching. We demonstrate that 3D confinement combined with modulation of cell-c...

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Literature Corpus work: f37e4ad9-63a5-5c16-a4ea-69e842dba5b3
DOI: 10.1101/2020.11.01.363713

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