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Confined 3D microenvironment regulates early differentiation in human pluripotent stem cells

4 Jun 2012

Abstract excerpt

The therapeutic potential of human pluripotent stem (hPS) cells is threatened, among various problems, by the difficulty to homogenously direct cell differentiation into specific lineages. The transition from hPSC into committed differentiated cells is accompanied by secretome activity, remodeling of extracellular matrix and self-organization into germ layers. In this work, we aimed to investigate how different...

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PMID: 22674472
DOI: 10.1002/bit.24571

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