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Article

Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling.

Scientific reports - 15 Jan 2020

Legøy Thomas Aga, Vethe Heidrun, Abadpour Shadab, Strand Berit L, Scholz Hanne, Paulo Joao A, Ræder Helge, Ghila Luiza, Chera Simona

Abstract excerpt

Cell replacement therapies hold great therapeutic potential. Nevertheless, our knowledge of the mechanisms governing the developmental processes is limited, impeding the quality of differentiation protocols. Generating insulin-expressing cells in vitro is no exception, with the guided series of differentiation events producing heterogeneous cell populations that display mixed pancreatic islet phenotypes and...

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Identifiers

PMID: 31942009
DOI: 10.1038/s41598-019-57305-x
PMCID: PMC6962451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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