TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices.

doi:10.1111/bpa.12190

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Article

TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices.

Brain pathology (Zurich, Switzerland) - 1 Jul 2015

Lue Lih-Fen, Schmitz Christopher T, Serrano Geidy, Sue Lucia I, Beach Thomas G, Walker Douglas G

Abstract excerpt

Triggering receptor expressed by myeloid cells 2 (TREM2), a member of the immunoglobulin superfamily, has anti-inflammatory phagocytic function in myeloid cells. Several studies have shown that TREM2 gene variant rs75932628-T increased the risks for Alzheimer's disease (AD), Parkinson's disease, frontotemporal dementia and amyotrophic lateral sclerosis. It has been suggested that the risks could be resulted from...

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Identifiers

PMID: 25186950
DOI: 10.1111/bpa.12190
PMCID: PMC4427527

Genes

TREM2
SNAP25

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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