Article

Deficiency in endocannabinoid synthase <i>DAGLB</i> contributes to Parkinson’s disease and dopaminergic neuron dysfunction

2021-12-09

Abstract excerpt

2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid (eCB) in the brain, regulates diverse neural functions. However, whether 2-AG deficiency contributes to Parkinson’s disease (PD) and nigral dopaminergic neurons (DANs) dysfunction is unclear. Diacylglycerol lipase α and β ( DAGLA and DAGLB ) mediate the biosynthesis of 2-AG. Using homozygosity mapping and whole-exome sequencing, we linked multiple...

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Literature Corpus work: f331b7a9-31d1-567c-a608-cc811021e65b
DOI: 10.1101/2021.12.09.471983

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Deficiency in endocannabinoid synthase <i>DAGLB</i> contributes to Parkinson’s disease and dopaminergic neuron dysfunctionDOI 10.1101/2021.12.09.471983Read

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