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Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways.

Molecular neurobiology - 1 Aug 2018

Sánchez Elena, Azcona Luis J, Paisán-Ruiz Coro

Abstract excerpt

This study aimed to gain insights into the pathophysiology underlying PLA2G6-associated neurodegeneration that is implicated in three different neurological disorders, suggesting that other, unknown genetic or environmental factors might contribute to its wide phenotypic expression. To accomplish this, we downregulated the function of pla2g6 in the zebrafish nervous system, performed parkinsonism-related...

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PMID: 29344929
DOI: 10.1007/s12035-017-0846-2

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