Back to search

Article

DAGLα/β, 2-AG release, and Parkinson’s Disease: Exploring a causal link

2025-04-23

Abstract excerpt

The diacylglycerol lipases, DAGLα and DAGLβ, hydrolyse diacylglycerol (DAG) to produce 2-arachidonoylglycerol (2-AG), a key endocannabinoid (eCB) and CB 1 /CB 2 receptor ligand. While DAGLα is well established as a regulator of CB 1 -dependent synaptic plasticity, recent studies have identified DAGLB mutations as a cause of autosomal recessive early-onset Parkinson’s disease (PD). Here, we present a comprehens...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
124061fe-fb7c-579f-ab66-ec8cd9b393c9
DOI
10.1101/2025.04.17.649373
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
DAGLα/β, 2-AG release, and Parkinson’s Disease: Exploring a causal linkDOI 10.1101/2025.04.17.649373
Deficiency in endocannabinoid synthase <i>DAGLB</i> contributes to Parkinson’s disease and dopaminergic neuron dysfunctionSemantic proximity
Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders.Semantic proximity
From Synaptic Plasticity to Neurotoxicity: Endocannabinoid Influence on Addiction and NeurodegenerationSemantic proximity
Overabundant endocannabinoids in neurons are detrimental to cognitive functionSemantic proximity
AP-4 mediates vesicular transport of the 2-AG endocannabinoid producing enzyme DAGLBSemantic proximity
A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization.Semantic proximity
The Interplay between 2-Arachidonoylglycerol and Anandamide Amidohydrolase in NeuropathySemantic proximity
Activation of central cannabinoid type 2 receptors, but not on peripheral immune cells, is required for endocannabinoid-mediated neuroprotection in Parkinson´s diseaseSemantic proximity
Cholesterol in the Pathogenesis of Alzheimer’s, Parkinson’s Diseases and Autism: Link to Synaptic DysfunctionSemantic proximity
Peripheral Upregulation of Parkinson's Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression.Semantic proximity
The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's Disease.Semantic proximity
Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer’s Disease in a Preclinical Model: A Therapeutic OpportunitySemantic proximity
Select a neighboring publication to make it the new centre.