Article

AP-4 mediates vesicular transport of the 2-AG endocannabinoid producing enzyme DAGLB

2020-10-25

Abstract excerpt

The adaptor protein complex AP-4 mediates anterograde axonal transport and is essential for axon health. AP-4-deficient patients suffer from a severe neurological disorder, which encompasses neurodevelopmental and neurodegenerative features. While impaired autophagy has been suggested to account for axon degeneration in AP-4 deficiency, axon growth defects occur through an unknown mechanism. Here we use orthogonal...

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Literature Corpus work: 6736694a-9dd7-5b1c-892b-022fe9eac556
DOI: 10.1101/2020.10.25.353995

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