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Article

A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization.

Molecular pharmacology - 1 Sept 2007

Jung Kwang-Mook, Astarita Giuseppe, Zhu Chenggang, Wallace Matthew, Mackie Ken, Piomelli Daniele

Abstract excerpt

Activation of group I metabotropic glutamate (mGlu) receptors recruits the endocannabinoid system to produce both short- and long-term changes in synaptic strength in many regions of the brain. Although there is evidence that the endocannabinoid 2-arachidonoylglycerol (2-AG) mediates this process, the molecular mechanism underlying 2-AG mobilization remains unclear. In the present study, we used a combination of...

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Identifiers

PMID: 17584991
DOI: 10.1124/mol.107.037796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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