Article
Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction.
Molecular genetics and metabolism - 1 Feb 2014
Ginns Edward I, Mak Sally K-K, Ko Novie, Karlgren Juliane, Akbarian Schahram, Chou Vivian P, Guo Yin, Lim Arlene, Samuelsson Steven, LaMarca Mary L, Vazquez-DeRose Jacqueline, Manning-Boğ Amy B
Abstract excerpt
Clinical, epidemiological and experimental studies confirm a connection between the common degenerative movement disorder Parkinson's disease (PD) that affects over 1 million individuals, and Gaucher disease, the most prevalent lysosomal storage disorder. Recently, human imaging studies have implicated impaired striatal dopaminergic neurotransmission in early PD pathogenesis in the context of Gaucher disease...
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