Article

<i>De novo</i> human brain enhancers created by single nucleotide mutations

2021-07-05

Abstract excerpt

Advanced human cognition is attributed to increased neocortex size and complexity, but the underlying gene regulatory mechanisms are unknown. Using deep learning model of embryonic neocortical enhancers, and human and macaque embryonic neocortex H3K27ac data, we identified ~4000 enhancers gained de novo in the human, largely attributable to single-nucleotide essential mutations. The genes near de novo gained enh...

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Literature Corpus work: f320631a-19d5-53b5-9bcf-2eebf24b99f1
DOI: 10.1101/2021.07.04.451055

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