Article

De novo human brain enhancers created by single nucleotide mutations

2021-08-12

Abstract excerpt

Advanced human cognition is attributed to increased neocortex size and complexity, but the underlying gene regulatory mechanisms are unknown. Using deep learning model of embryonic neocortical enhancers, and human and macaque embryonic neocortex H3K27ac data, we identified ~4000 enhancers gained in the human, largely attributable to single-nucleotide essential mutations. The genes near gained enhancers exhibit inc...

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Literature Corpus work: fcfaca22-19d8-51db-bb4e-623a9104796e
DOI: 10.21203/rs.3.rs-765891/v1

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