Article

Identification of essential regulatory elements in the human genome

2018-10-16

Abstract excerpt

The identification of essential regulatory elements is central to the understanding of the consequences of genetic variation. Here we use novel genomic data and machine learning techniques to map essential regulatory elements and to guide functional validation. We train an XGBoost model using 38 functional and structural features, including genome essentiality metrics, 3D genome organization and enhancer reporter...

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Literature Corpus work: 8867f2ed-6f2e-5cae-beb7-f433887194fd
DOI: 10.1101/444562

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