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HNF1α maintains pancreatic α and β cell functions in primary human islets

9 Nov 2023

Abstract excerpt

HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes (HNF1A-maturity onset diabetes of the young [HNF1A-MODY]), and hypomorphic HNF1A variants confer type 2 diabetes risk. But a lack of experimental systems for interrogating mature human islets has limited our understanding of how the transcription factor HNF1α regulates adult islet function. Here, we combined conditional genetic...

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PMID: 37943614
DOI: 10.1172/jci.insight.170884

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