Article

HNF1α transcriptional activation and repression maintain human islet α and β cell function

2022-09-25

Abstract excerpt

<h4>ABSTRACT</h4> HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes (HNF1A-MODY) and hypomorphic HNF1A variants confer type 2 diabetes risk, but a lack of experimental systems has limited our understanding of how the transcription factor HNF1α regulates adult human islet function. Here, we combined human islet genetics, RNA sequencing, Cleavage Under Targets & Release Using Nucl...

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Literature Corpus work: 1601afb9-22bb-52c6-8ad5-622c20647892
DOI: 10.1101/2022.09.25.509394

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