Article
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells.
Nature communications - 25 May 2021
Low Blaise Su Jun, Lim Chang Siang, Ding Shirley Suet Lee, Tan Yaw Sing, Ng Natasha Hui Jin, Krishnan Vidhya Gomathi, Ang Su Fen, Neo Claire Wen Ying, Verma Chandra S, Hoon Shawn, Lim Su Chi, Tai E Shyong, Teo Adrian Kee Keong
Abstract excerpt
Heterozygous HNF1A gene mutations can cause maturity onset diabetes of the young 3 (MODY3), characterized by insulin secretion defects. However, specific mechanisms of MODY3 in humans remain unclear due to lack of access to diseased human pancreatic cells. Here, we utilize MODY3 patient-derived human induced pluripotent stem cells (hiPSCs) to study the effect(s) of a causal HNF1A+/H126D mutation on pancreatic...
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