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Article

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.

The Journal of biological chemistry - 24 Feb 2006

Miura Atsuko, Yamagata Kazuya, Kakei Masafumi, Hatakeyama Hiroyasu, Takahashi Noriko, Fukui Kenji, Nammo Takao, Yoneda Kazue, Inoue Yusuke, Sladek Frances M, Magnuson Mark A, Kasai Haruo, Miyagawa Junichiro, Gonzalez Frank J, Shimomura Iichiro

Abstract excerpt

Mutations in the hepatocyte nuclear factor (HNF)-4alpha gene cause a form of maturity-onset diabetes of the young (MODY1) that is characterized by impairment of glucose-stimulated insulin secretion by pancreatic beta-cells. HNF-4alpha, a transcription factor belonging to the nuclear receptor superfamily, is expressed in pancreatic islets as well as in the liver, kidney, and intestine. However, the role of...

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PMID: 16377800
DOI: 10.1074/jbc.M507496200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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