Article

Human stem cell model of <i>HNF1A</i> deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules

2021-01-26

Abstract excerpt

Mutations in HNF1A cause Maturity Onset Diabetes of the Young type 3 (MODY3), the most prevalent form of monogenic diabetes. We generated stem cell-derived pancreatic endocrine cells from human embryonic stem cells (hESCs) with induced hypomorphic mutations in HNF1A . Using these cells, we show that HNF1A orchestrates a transcriptional program required for distinct aspects of β-cell fate and function. During is...

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Literature Corpus work: 825a212b-b8a3-5bb3-b9ab-1f3a0b09b418
DOI: 10.1101/2021.01.26.428260

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