Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster.

doi:10.1016/j.molmet.2024.102013

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster.

Molecular metabolism - 1 Nov 2024

Mahmoudzadeh Nader H, Heidarian Yasaman, Tourigny Jason P, Fitt Alexander J, Beebe Katherine, Li Hongde, Luhur Arthur, Buddika Kasun, Mungcal Liam, Kundu Anirban, Policastro Robert A, Brinkley Garrett J, Zentner Gabriel E, Nemkov Travis, Pepin Robert, Chawla Geetanjali, Sudarshan Sunil, Rodan Aylin R, D'Alessandro Angelo, Tennessen Jason M

Abstract excerpt

OBJECTIVES: The mitochondrial enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) regulates the abundance of L-2-hydroxyglutarate (L-2HG), a potent signaling metabolite capable of influencing chromatin architecture, mitochondrial metabolism, and cell fate decisions. Loss of L2hgdh activity in humans induces ectopic L-2HG accumulation, resulting in neurodevelopmental defects, altered immune cell function, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Oxidoreductases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Glutarates

Share to Hypoxia

Share to Kidney

Share to Mitochondria

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 39182840
DOI: 10.1016/j.molmet.2024.102013
PMCID: PMC11408159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster.PMID 39182840Read ↗

New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in Drosophila melanogaster.Semantic proximity Read ↗

The oncometabolite L-2-hydroxyglutarate is a common product of Dipteran larval developmentSemantic proximity Read ↗

A Drosophila model of combined D-2- and L-2-hydroxyglutaric aciduria reveals a mechanism linking mitochondrial citrate export with oncometabolite accumulation.Semantic proximity Read ↗

New alleles of <i>D-2-hydroxyglutarate dehydrogenase</i> enable studies of oncometabolite function in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.Semantic proximity Read ↗

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.Semantic proximity Read ↗

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.Semantic proximity Read ↗

Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4Semantic proximity Read ↗

SLC22 Transporters in the Fly Renal System Regulate Response to Oxidative Stress In VivoSemantic proximity Read ↗

Modeling Renal Disease “On the Fly”Semantic proximity Read ↗

Drosophila as a toolkit to tackle cancer and its metabolismSemantic proximity Read ↗

Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.