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Article

New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in Drosophila melanogaster.

G3 (Bethesda, Md.) - 6 Aug 2025

Rai Madhulika, Okah Prince, Shefali Shefali A, Fitt Alexander J, Shen Michael Z, Molomjamts Mandkhai, Pepin Robert, Nemkov Travis, D'Alessandro Angelo, Tennessen Jason M

Abstract excerpt

D-2-hydroxyglutarate (D-2HG) is a potent oncometabolite capable of disrupting chromatin architecture, altering metabolism, and promoting cellular dedifferentiation. As a result, ectopic D-2HG accumulation induces neurometabolic disorders and promotes progression of multiple cancers. However, the disease-associated effects of ectopic D-2HG accumulation are dependent on genetic context. Specifically, neomorphic...

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Identifiers

PMID: 40489577
DOI: 10.1093/g3journal/jkaf132
PMCID: PMC12341949

Genes

IDH1
IDH2

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