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Article

Quantitative Analysis of Oncometabolite 2-Hydroxyglutarate.

Advances in experimental medicine and biology - 1 Jan 2021

Yuan Bi-Feng

Abstract excerpt

Gain-of-function mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) were demonstrated to induce the production and accumulation of oncometabolite 2-hydroxyglutarate (2HG). 2HG is a potent competitor of α-ketoglutarate (α-KG) and can inhibit multiple α-KG-dependent dioxygenases that are critical for regulating the metabolic and epigenetic state of cells. The accumulation of 2HG contributes to elevated risk of...

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Mutation
Neoplasms
Glutarates
Isocitrate Dehydrogenase

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33791981
DOI: 10.1007/978-3-030-51652-9_11

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