Article

Both Enantiomers of 2-Hydroxyglutarate Modulate the Metabolism of Cultured Human Neuroblastoma Cells

2024-03-05

Abstract excerpt

<title>Abstract</title> <p>Elevated levels of D-2-hydroxyglutarate (D-2HG) and L-2-hydroxyglutarate (L-2HG) in the brain are associated with various pathological conditions, potentially contributing to neurological symptoms and neurodegeneration. Previous studies on animal models have revealed their capability to interfere with several cellular processes, including mitochondrial metabolism. Both enantiomers compe...

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Literature Corpus work: fbbcb0ec-b5fa-5548-b55e-7a6ad11d7248
DOI: 10.21203/rs.3.rs-3993891/v1

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