Article

Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism

2020-04-16

Abstract excerpt

<h4>Background and Purpose</h4> alkaptonuria (AKU) is an inherited disorder of tyrosine metabolism caused by lack of the enzyme homogentisate 1,2-dioxygenase (HGD). The primary biochemical consequence of HGD-deficiency is increased circulating homogentisic acid (HGA), which is central to AKU disease pathology. The aim of this study was to investigate the wider metabolic consequences of targeted Hgd disruption....

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Literature Corpus work: f2da17de-aefb-5896-a152-a01f53cf970b
DOI: 10.1101/2020.04.16.044347

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