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L-2-hydroxyglutarate regulates centromere and heterochromatin conformation in the male germline

10 Jul 2025

Abstract excerpt

Germ cell differentiation in the male testis involves extensive phenotypic, transcriptional, and epigenetic modifications, which are essential for producing functional spermatozoa. Among all organs, the testis exhibits the highest baseline physiological levels of L-2-hydroxyglutarate (L-2HG), yet its role in male germ cell development remains unknown. Here, we reveal that L-2HG is synthesized during the pachytene...

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PMID: 40638696
DOI: 10.1371/journal.pgen.1011785

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