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Article

2-hydroxyglutarate rides the cancer-immunity cycle.

Current opinion in biotechnology - 1 Oct 2023

Foskolou Iosifina P, Bunse Lukas, Van den Bossche Jan

Abstract excerpt

2-hydroxyglutarate (2HG) is a biproduct of the Krebs cycle, which exists in a D- and L- enantiomer and is structurally similar to α-ketoglutarate. Both 2HG enantiomers have been described to accumulate in diverse cancer and immune cells and can influence cell fate and function. While D-2HG was originally considered as an 'oncometabolite' that aberrantly builds up in certain cancers, it is becoming clear that it...

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Identifiers

PMID: 37515937
DOI: 10.1016/j.copbio.2023.102976

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