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New alleles of <i>D-2-hydroxyglutarate dehydrogenase</i> enable studies of oncometabolite function in <i>Drosophila melanogaster</i>

2025-04-01

Abstract excerpt

<h4>ABSTRACT</h4> D-2-hydroxyglutarate (D-2HG) is a potent oncometabolite capable of disrupting chromatin architecture, altering metabolism, and promoting cellular dedifferentiation. As a result, ectopic D-2HG accumulation induces neurometabolic disorders and promotes progression of multiple cancers. However, the disease-associated effects of ectopic D-2HG accumulation are dependent on genetic context. Specifical...

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Literature Corpus work
590cab1a-0b95-5970-9cf8-909858d106c8
DOI
10.1101/2025.03.27.645621
Open publication

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New alleles of <i>D-2-hydroxyglutarate dehydrogenase</i> enable studies of oncometabolite function in <i>Drosophila melanogaster</i>DOI 10.1101/2025.03.27.645621
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