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Article

Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2016

Kouvatsos Nikolaos, Giastas Petros, Chroni-Tzartou Dafni, Poulopoulou Cornelia, Tzartos Socrates J

Abstract excerpt

In this study we report the X-ray crystal structure of the extracellular domain (ECD) of the human neuronal α2 nicotinic acetylcholine receptor (nAChR) subunit in complex with the agonist epibatidine at 3.2 Å. Interestingly, α2 was crystallized as a pentamer, revealing the intersubunit interactions in a wild type neuronal nAChR ECD and the full ligand binding pocket conferred by two adjacent α subunits. The...

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Source

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Identifiers

PMID: 27493220
DOI: 10.1073/pnas.1602619113
PMCID: PMC5003238

Genes

ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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