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Article

Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective.

Neuropharmacology - 1 Aug 2016

Andersen Natalia D, Nielsen Beatriz E, Corradi Jeremías, Tolosa María F, Feuerbach Dominik, Arias Hugo R, Bouzat Cecilia

Abstract excerpt

Enhancement of α7 nicotinic receptor (nAChR) function by positive allosteric modulators (PAMs) is a promising therapeutic strategy to improve cognitive deficits. PAMs have been classified only on the basis of their macroscopic effects as type I, which only enhance agonist-induced currents, and type II, which also decrease desensitization and reactivate desensitized nAChRs. To decipher the molecular basis...

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Identifiers

PMID: 26926428
DOI: 10.1016/j.neuropharm.2016.02.032

Genes

PAM

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