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Article

Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain.

Nature structural & molecular biology - 1 Nov 2014

Zouridakis Marios, Giastas Petros, Zarkadas Eleftherios, Chroni-Tzartou Dafni, Bregestovski Piotr, Tzartos Socrates J

Abstract excerpt

We determined the X-ray crystal structures of the extracellular domain (ECD) of the monomeric state of human neuronal α9 nicotinic acetylcholine receptor (nAChR) and of its complexes with the antagonists methyllycaconitine and α-bungarotoxin at resolutions of 1.8 Å, 1.7 Å and 2.7 Å, respectively. The structure of the monomeric α9 ECD superimposed well with the structures of homologous proteins in pentameric...

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PMID: 25282151
DOI: 10.1038/nsmb.2900

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ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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