Article

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

2022-09-28

Abstract excerpt

Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular level understanding of the general principals that govern the myriad pharmacological effects exerted by GPCR allosteric modulators remains limited. The M 4 muscarinic acetylcholine receptor (M 4 mAChR) is a well-validated and clinically relevant allosteric drug target for s...

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Literature Corpus work: 0bb1a04c-f796-5766-9e59-eec98316bc36
DOI: 10.1101/2022.09.27.509640

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