Article

The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor Radioresponse

2009-01-01

Abstract excerpt

Tumor growth and progression is a complex phenomenon dependent on the interaction of multiple intrinsic and extrinsic factors. Necessary for tumor development is a small subpopulation of potent cells, so-called cancer stem cells, that can undergo an unlimited number of cell divisions and which are proposed to divide symmetrically with a small probability to produce more cancer stem cells. We show that the majority...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2dffc8b-9d93-5d34-ba27-d750ed711538
DOI: 10.1051/mmnp/20094305

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor RadioresponseDOI 10.1051/mmnp/20094305Read

Cancer stem cells: small subpopulation or evolving fraction?Semantic proximity Read

Estimating stem cell fractions in hierarchically organized tumorsSemantic proximity Read

Non-stem cancer cell kinetics modulate solid tumor progressionSemantic proximity Read

Cancer stem cells and tumor dormancy.Semantic proximity Read

Paradoxical Dependencies of Tumor Dormancy and Progression on Basic Cell KineticsSemantic proximity Read

Determinants of stem cell enrichment in healthy tissues and tumors: implications for non-genetic drug resistanceSemantic proximity Read

Evolution and phenotypic selection of cancer stem cells.Semantic proximity Read

The therapeutic implications of plasticity of the cancer stem cell phenotype.Semantic proximity Read

A mathematical model of cancer stem cell driven tumor initiation: implications of niche size and loss of homeostatic regulatory mechanisms.Semantic proximity Read

Acute and Fractionated Irradiation Differentially Modulate Glioma Stem Cell Division KineticsSemantic proximity Read

Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational simulation studySemantic proximity Read

Cancer Stem Cells: A Minor Cancer Subpopulation that Redefines Global Cancer FeaturesSemantic proximity Read