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Article

Acute and Fractionated Irradiation Differentially Modulate Glioma Stem Cell Division Kinetics

26 Dec 2012

Abstract excerpt

Glioblastoma multiforme (GBM) is one of the most aggressive human malignancies with a poor patient prognosis. Ionizing radiation either alone or adjuvant after surgery is part of standard treatment for GBM but remains primarily noncurative. The mechanisms underlying tumor radioresistance are manifold and, in part, accredited to a special subpopulation of tumorigenic cells. The so-called glioma stem cells (GSC)...

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PMID: 23269274
DOI: 10.1158/0008-5472.can-12-3429

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