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Article

Non-stem cancer cell kinetics modulate solid tumor progression

1 Dec 2011

Abstract excerpt

BACKGROUND: Solid tumors are heterogeneous in composition. Cancer stem cells (CSCs) are believed to drive tumor progression, but the relative frequencies of CSCs versus non-stem cancer cells span wide ranges even within tumors arising from the same tissue type. Tumor growth kinetics and composition can be studied through an agent-based cellular automaton model using minimal sets of biological assumptions and...

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PMID: 22208390
DOI: 10.1186/1742-4682-8-48

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