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Article

Evolution and phenotypic selection of cancer stem cells.

PLoS computational biology - 1 Mar 2015

Poleszczuk Jan, Hahnfeldt Philip, Enderling Heiko

Abstract excerpt

Cells of different organs at different ages have an intrinsic set of kinetics that dictates their behavior. Transformation into cancer cells will inherit these kinetics that determine initial cell and tumor population progression dynamics. Subject to genetic mutation and epigenetic alterations, cancer cell kinetics can change, and favorable alterations that increase cellular fitness will manifest themselves and...

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Identifiers

PMID: 25742563
DOI: 10.1371/journal.pcbi.1004025
PMCID: PMC4351192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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