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Article

The therapeutic implications of plasticity of the cancer stem cell phenotype.

PloS one - 17 Dec 2010

Leder Kevin, Holland Eric C, Michor Franziska

Abstract excerpt

The cancer stem cell hypothesis suggests that tumors contain a small population of cancer cells that have the ability to undergo symmetric self-renewing cell division. In tumors that follow this model, cancer stem cells produce various kinds of specified precursors that divide a limited number of times before terminally differentiating or undergoing apoptosis. As cells within the tumor mature, they become...

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Identifiers

PMID: 21179426
DOI: 10.1371/journal.pone.0014366
PMCID: PMC3003707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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