Article

Determinants of stem cell enrichment in healthy tissues and tumors: implications for non-genetic drug resistance

2019-06-06

Abstract excerpt

Drug resistance is a major challenge for cancer therapy. While resistance mutations are often the focus of investigation, non-genetic resistance mechanisms are also important. One such mechanism is the presence of relatively high fractions of cancer stem cells (CSCs), which have reduced susceptibility to chemotherapy, radiation, and targeted treatments compared to more differentiated cells. The reasons for high CS...

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Literature Corpus work: d4d9ae1b-c35f-53b0-81d9-c96bcd851824
DOI: 10.1101/663146

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