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Cancer stem cells: small subpopulation or evolving fraction?

24 Oct 2014

Abstract excerpt

Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell...

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PMID: 25359461
DOI: 10.1039/c4ib00191e

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