Article
Hypometabolism as the ultimate defence in stress response: how the comparative approach helps understanding of medically relevant questions
1 Jul 2016
Abstract excerpt
Abstract First conceptualized from breath‐hold diving mammals, later recognized as the ultimate cell autonomous survival strategy in anoxia‐tolerant vertebrates and burrowing or hibernating rodents, hypometabolism is typically recruited by resilient organisms to withstand and recover from otherwise life‐threatening hazards. Through the coordinated down‐regulation of biosynthetic, proliferative and electrogenic...
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