Article

Cell type-specific gene expression dynamics during human brain maturation

2023-09-29

Abstract excerpt

The human brain undergoes protracted post-natal maturation, guided by dynamic changes in gene expression. Most studies exploring these processes have used bulk tissue analyses, which mask cell type-specific gene expression dynamics. Here, using single nucleus (sn)RNA-seq on temporal lobe tissue, including samples of African ancestry, we build a joint paediatric and adult atlas of 75 cell subtypes, which we verify...

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Literature Corpus work: 560f9eb4-58ba-5752-a879-63c93d125b67
DOI: 10.1101/2023.09.29.560114

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