Article
Unblinding the watchmaker: cancer treatment and drug design in the face of evolutionary pressure.
Expert opinion on drug discovery - 1 Oct 2022
Konig Sophia, Strobel Hannah, Grunert Michael, Lyszkiewicz Marcin, Brühl Oliver, Karpel-Massler Georg, Ziętara Natalia, La Ferla-Brühl Katia, Siegelin Markus D, Debatin Klaus-Michael, Westhoff Mike-Andrew
Abstract excerpt
INTRODUCTION: Death due to cancer is mostly associated with therapy ineffectiveness, i.e. tumor cells no longer responding to treatment. The underlying dynamics that facilitate this mutational escape from selective pressure are well studied in several other fields and several interesting approaches exist to combat this phenomenon, for example in the context of antibiotic-resistance in bacteria. AREAS COVERED:...
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