Article
Evolution of resistance during clonal expansion.
Genetics - 1 Apr 2006
Iwasa Yoh, Nowak Martin A, Michor Franziska
Abstract excerpt
Acquired drug resistance is a major limitation for cancer therapy. Often, one genetic alteration suffices to confer resistance to an otherwise successful therapy. However, little is known about the dynamics of the emergence of resistant tumor cells. In this article, we consider an exponentially growing population starting from one cancer cell that is sensitive to therapy. Sensitive cancer cells can mutate into...
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