Impacts of competition and phenotypic plasticity on the viability of adaptive therapy

Abstract excerpt

Cancer is heterogeneous and variability in drug sensitivity is widely documented across cancer types. Adaptive therapy is an emerging modality of cancer treatment that leverages this drug resistance heterogeneity to improve therapeutic outcomes. Current standard treatments typically eliminate a large fraction of drug-sensitive cells, leading to drug-resistant relapse due to competitive release. Adaptive therapy ai...

Topics

Open a Topic to create a Post that cites this publication.

• Algorithms
• Cell Proliferation
• Computer Simulation
• Drug Resistance, Neoplasm
• Immunotherapy
• Models, Biological
• Neoplasms
• Phenotype

Identifiers and source

Literature Corpus work

912cdac6-ef68-55c8-a9bb-98f8d55c0867

DOI

10.1101/2025.03.20.644475