Article

Heterogeneous therapy-resistant cancer cells have distinct and exploitable drug sensitivity profiles

2025-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Resistance to targeted therapies is a significant clinical problem, but eliminating resistant cancer cells has proven difficult. One potential reason for this difficulty is heterogeneity in the resistant population: even genetically homogeneous cancer cell populations can give rise to many resistant subtypes, each potentially with specific second-line drug vulnerabilities. Using high-throughput...

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Literature Corpus work: f9863c60-a709-59af-9e5d-96da4033f0d2
DOI: 10.1101/2025.04.25.650475

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