Article

Single cell fitness landscapes induced by genetic and pharmacologic perturbations in cancer

2020-05-09

Abstract excerpt

Tumour fitness landscapes underpin selection in cancer, impacting etiology, evolution and response to treatment. Progress in defining fitness landscapes has been impeded by a lack of timeseries perturbation experiments over realistic intervals at single cell resolution. We studied the nature of clonal dynamics induced by genetic and pharmacologic perturbation with a quantitative fitness model developed to ascribe...

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Literature Corpus work: c9ed3627-52ce-5d28-8452-781b66912b11
DOI: 10.1101/2020.05.08.081349

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